Multi-Drug Scheduling for Chemotherapy Using Fractional Order Internal Model Controller

Chemotherapy is a widely used cancer treatment method globally. However, cells can develop resistance towards single-drug-based chemotherapy if it infused for extended periods, resulting in failure many cases. To address this issue, oncologists have progressed using multi-drug (MDC). This considers different drug concentrations treatment, but choosing incorrect adversely affect the patient’s body. Therefore, crucial to recognize trade-off between and their adverse effects. closed-loop scheduling based on Fractional Order Internal-Model-Control Proportional Integral (IMC-FOPI) Control proposed. The proposed scheme combines benefits of fractional PI internal model controllers. Additionally, parameters IMC-FOPI are optimally tuned random walk-based Moth-flame optimization. performance controller compared with Two degrees freedom (2PI) controllers concentration control at tumor site. results reveal that improves settling time by 43% 21% VX, 54% 48 % VY, 48% 40% VZ, respectively, 2PI. be concluded more efficient than conventional